Effects of dietary excess amino acids on the concentrations of cholesterol, .ALPHA.-tocopherol, ascorbic acid, and copper in serum and tissues of rats.

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An experiment was conducted with growing rats to inves-tigate the effects of feeding excessive specific L-amino acids for 8 days on serum and tissue cholesterol, α-tocopherol, ascorbic acid, and copper, and on liver microsomal cytochrome P-450. To a 10% casein diet were added 4% L-methionine, 5% L-cystine, 5% L-histidine, 5% L-threonine, 5% L-tryptophan, 5% L-phenylalanine, 5% L-tyrosine, 6% L-valine, 7% L-isoleucine, 7% L-lysine, or 8% L-leucine. Excessive cystine and histi-dine increased serum cholesterol and α- tocopherol. Excessive cystine and methionine increased liver and kidney α-tocopherol and ascorbic acid. Excessive tyrosine and phenylalanine caused a marked increase in serum copper and ceruloplasmin activity, whereas excessive cystine, methionine, and histidine caused a decrease in the ceruloplasmin activity. Excessive histidine increased liver cytochrome P-450, whereas excessive tyrosine markedly decreased liver cytochrome P-450.