Effect of Nicotine on Norepinephrine Turnover and Thermogenesis in Brown Adipose Tissue and Metabolic Rate in MSG Obese Mice

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概要

• 論文の詳細を見る

• To clarify whether nicotine stimulates the sympathetic nervous system (SNS) and thermogenesis in brown adipose tissue (BAT) and whether it promotes the resting metabolic rate (RMR), with resulting mitigation of obesity, we measured norepinephrine (NE) turnover (an indicator of SNS activity), guanosine-5-diphosphate (GDP) binding (a thermogenic indicator), oxygen consumption in BAT, and RMR in monosodium-L-glutamate (MSG) obese and saline control mice after 2 weeks treatment with nicotine. Nicotine significantly increased NE turnover, GDP binding, oxygen consumption in BAT, and RMR, and significantly reduced body weight in MSG obese mice as well as in control mice without affecting food intake. These results suggest that nicotine stimulates NE turnover and thermogenesis in BAT, and promotes RMR, all of which contribute to the mitigation of obesity.

著者

• 吉田 俊秀

  First Department of Internal Medicine

• 吉岡 敬治

  First Department of Internal Medicine

• 近藤 元治

  First Department of Internal Medicine

• 平岡 範也

  First Department of Internal Medicine, Kyoto Prefectural University of Medicine

• 近藤 元治

  First Department of Internal Medicine, Kyoto Prefectural University of Medicine

• 吉岡 敬治

  First Department of Internal Medicine, Kyoto Prefectural University of Medicine

関連論文

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• Effect of Nicotine on Norepinephrine Turnover and Thermogenesis in Brown Adipose Tissue and Metabolic Rate in MSG Obese Mice
• Mitigation of Obesity by BRL 2b830A, a New β-Adreno-ceptor Agonist, in MSG Obese Mice
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