Mitigation of Obesity by BRL 2b830A, a New β-Adreno-ceptor Agonist, in MSG Obese Mice

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概要

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• Half of the mice in both the monosodium-L-glutamate (MSG)-induced obesity and saline control groups were given BRL 26830A via a gastric tube at a daily dose of 5mg/kg for 2 weeks, and the other half given distilled water. BRL 26830A administration significantly increased guanosine-5-diphosphate (GDP)-binding in brown adipose tissue (BAT) and the resting metabolic rate (RMR), and significantly reduced re-troperitoneal white adipose tissue (WAT) pads in both groups. It also markedly reduced body weight in MSG obese mice that had reduced BAT thermogenesis and decreased RMR. However, food intake was unchanged in both groups. Neither β1- nor β2-selective antagonists affected the increase of RMR induced by BRL 26830A, but a non-selective β-antagonist completely inhibited its increase. These results suggest that BRL 26830A, which is a new β-adrenoceptorr agonist, stimulates BAT thermogenesis, increases RMR, and reduces WAT, thus contributing to the mitigation of obesity.

著者

• 吉田 俊秀

  First Department of Internal Medicine

• 吉岡 敬治

  First Department of Internal Medicine

• 近藤 元治

  First Department of Internal Medicine

• 平岡 範也

  First Department of Internal Medicine, Kyoto Prefectural University of Medicine

• 釜鳴 孝吉

  First Department of Internal Medicine, Kyoto Prefectural University of Medicine

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