口腔感染症における生体防禦機能の評価

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Neutrophils are thought to play an important role in the host defensive system against bacterial infections. Previously, we reported that peripheral blood neutrophil function was enhanced in acute bacterial infections and that elevated neutrophil activity returned to normal following recovery. In this study, peripheral blood neutrophil function of the patients with oral serious infections was investigated in order to elucidate the mechanism of its occurrence and persistence.<BR>For this purpose, peripheral blood neutrophils were obtained from 7 patients with oral serious infections-namely, 3 patients with chronic osteomyelitis of the lower jaw, 2 patients with suspected actinomycosis of the jaw, one patient with radioosteomyelitis, and one patient with prolonged cellulitis of the mouth floor. Then, binding activity, chemotaxis, phagocytic and killing activity, and oxidative metabolic activity were estimated respectively. Killing activity was estimated by nitroblue tetrazolium reduction test and oxidative metabolic activity was measured by the production of luminol-dependent chemiluminescence.<BR>Although slight enhanced phagocytosis was observed, other neutrophil activities were decreased in the patients with oral serious infections. Especially, the production of luminoldependent chemiluminescence was markedly reduced when compared with that of normal volunteers. These results suggest that reduced killing activity may result in persistent or severe infections.
社団法人日本口腔外科学会の論文

口腔感染症における生体防禦機能の評価

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