実験的口腔腫瘍における細胞間結合装置に関する電子顕微鏡学的研究 : 9, 10-dimethyl-1, 2-benzantbracene誘発ハムスター舌癌形成過程における細胞間結合装置のフリーズフラクチャー電顕法による定量的観察

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概要

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• A 2% acetone solution of 9, 10-dimethy1-1, 2-benzanthracene (DMBA) was applied to lingual mucosa of hamsters after scratching with a root canal broach three times a week. Using mainly the freeze-fracture method, the quantitative study of intercellular junctional changes was made during the process of carcinogenesis and in squamous cell carcinoma in the oral mucosa of hamsters. Replicas were examined and photographed in a single blind fashion, and the frequency and size distribution of gap junctions and desmosomes were computed planimetrically. Precancerous lesions were classified into two groups:(a) mild and moderate dysplasia, and (b) severe dysplasia. The results obtained were as follows:<BR>1) Intercellular junctions were very frequent in the normal intermediate layer and less frequent in the normal basal single layer of cells.<BR>2) Gap junctions decreased significantly in the basal layer of the severe dysplasia and in the marginal area of the invasive carcinoma.<BR>3) Desmosomes decreased significantly in the intermediate layer of the severe dysplasia and in the invasive carcinoma.<BR>These results indicate that the decrease of intercellular junctions correlates with the severity of morphological alteration in the dysplastic epithelium and the deficiency of intercellular junctions before invasion may be one of the important factors eventually permitting the development of the diffusely infiltrating cells which are characteristic of highly malignant tumors such as squamous cell carcinoma.

著者

• 田畑 雅士

  鹿児島大学歯学部口腔外科学第一講座

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