Electron microscopic study on the effects of the tissue-Plasminogen Activator and Peplomycin to the experimental oral carcinogenesis

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It is widely accepted that acceleration of coagulation and inhibition of fibrinolysis have been found in malignant tumors. By breaking down the fibrin barrier surrounding the tumor mass, fibrinolytic enzymes (Urokinase and Dextran Sulfate) are able to elevate the concentration of antitumor agents reaching tumor tissue. This in turn, results in labilization and acceleration of lysosome release from tumor cells. In the present study, the effects of tissue-Plasminogen Activator (t-PA) and Peplomycin (PEP) singly or in combination, on cellular lysosome of experimentally induced hamster lingual carcinoma were assessed with acid phosphatase (ACPase) ultracytochemically. 1. In control group, the ACPase was demonstrated mainly in cellular lysosome and occasionally in golgi apparatus. 2. In the experimental group treated with t-PA 100×103 IU/kg alone, no significant ultrastructural change was noted. 3. In the experimental group treated with PEP 10 mg/kg alone, lysosome of tumor cells increased in number without obvious ultrastructural changes. 4. In the experimental group treated with t-PA and PEP in combination, cellular lysosome appeared enlarged and labilized with lysosomal enzymes released in the areas of cytoplasmic degeneration and necrosis. The present investigation suggested that t-PA, when treated in combination, was capable of elevating of the localized concentration of PEP reaching tumor tissue. Such findings implied that t-PA was able to increas the tumorcidal effect of PEP.
社団法人日本口腔外科学会の論文

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山下憲子
鹿児島大学歯学部第1口腔外科学教室

Electron microscopic study on the effects of the tissue-Plasminogen Activator and Peplomycin to the experimental oral carcinogenesis

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