Studies on IL-2 induced killer cells from immature T cells.
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Non-specific cytotoxic activity induced by Interleukin-2 (IL-2) was examined in the lymphoid tissues including the spleen, thymus and bone marrow. High cytotoxic activity against YAC-1 cells was induced by IL-2 in cells from all the lymphoid tissues but cytotoxic activity against P815 were rarely detected in bone marrow cells. In the thymocytes which contain T cells in various differentiation stages, it was demonstrated that Thy-1<SUP>+</SUP> L3T4 (CD4)<SUP>-</SUP>Lyt-2 (CD8)<SUP>-</SUP> cells were induced by IL-2 to express cytotoxic activity against YAC-1 but not against P815 in the embryo and adult mice. On the contary, IL-2 induced cytotoxic activity against P815 was found in the L3T4<SUP>-</SUP>Lyt-2<SUP>+</SUP> adult thymocytes but such activity was scarcely detectable in the same phenotype thymocytes of 15 day embryos which were induced by IL-2 during 6 day-organ culture. The Thy-1<SUP>+</SUP>L3T4<SUP>-</SUP> Lyt-2<SUP>-</SUP> cells obtained from nylon wool column passed spleen cells from athymic nude mice and SCID mouse thymocytes also showed high cytotoxic activity against YAC-1 but low activity against P815.<BR>These results suggest that IL-2 can induce cytotoxic activity in the immature thymocytes against NK sensitive and the L3T4<SUP>-</SUP> Lyt-2<SUP>+</SUP> mature T cells against both NK resistant and sensitive cells.
- 社団法人 日本口腔外科学会の論文
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