Ultrastructural study of vascular endothelium in the induced squamous cell carcinoma of the tongue. Effects of peplomycin or cisplatin on the vascular permeability.:Effects of peplomycin or cisplatin on the vascular permeability
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This study is designed to investigate the effects of antitumor agents, peplomycin (PEP) and cisplatin (CDDP), on vascular ultrastructural changes and the permeability of endothelium, using DMBA-induced squamous cell carcinoma of the tongue in golden hamsters. PEP and CDDP were administered daily for 7 days. Horseradish peroxidase (HRP) or tannic acid solution was injected as a tracer via the heart and the vasculature was fixed by perfusion after 15 seconds. The ultrastructural changes of capillaries and venules surrounding the cancer nests were observed by transmission electron microscopy. The occurrence of plasmalemmal vesicles, fenestrae and endothelial projections was less frequent in capillariesthan in venules in the saline, PEP and CDDP groups. This suggested that the venules were substantially associated with the permeability of the tumor vascular system. HRP was taken up by almost all the plasmalemmal vesicles existing on the luminal side of cell membrane. Tannic acid mostly penetrated through the fenestrae. In the PEP group, however there were a relatively large number of fenestrae sat inhibited tannic acid penetration. The occurrence of plasmalemmal vesicles and fenestrae was more frequent in the CDDP group than the other groups. These findings suggested that the vascular permeability was markedly augmented in the CDDP group compared to the PEP group. However the leakage of tannic acid was obstructed by the tight junction of intercellular spaces in the saline, PEP and CDDP groups.
- 社団法人 日本口腔外科学会の論文
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