Experimental study on microcirculation of the irradiated submandibular glands.
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Single irradiation for the submandibular glands of rats was performed at dose levels of 10 Gy and 30 Gy to study the changes following irradiation in the weight of the glands, the tissue blood flow, histopathology and to evaluate the vascular structure of the microcirculation after 30 Gy.<BR>The decrease in percentage weight of the submandibular glands in rats was 9.9%for 10 Gy and 20.3% for 30 Gy at 2 weeks following irradiation (p<0.01). It was 21.3% and 45.2%respectively at 3 months after (p<0.01).<BR>The tissue blood flow in the submandibular glands showed relative increases at 3 days and 1 and 2 weeks after irradiation in both the 10 Gy and 30 Gy groups, with peak values seen 1 week after irradiation. Thereafter the values decreased after 3 months following irradiation, there was a decrease of 4.7% in the 10 Gy group, but 27.1% in 30 Gy (p<0.001).<BR>Regarding histopathological changes of the submandibular glands in both the 10 Gy and 30 Gy groups, regressive changes progressed with time and 3 months after irradiation, atrophy of acinar cells and enlargement of the striated portion cells, fibrosis crevice between the acinic, around the excretory ducts and the blood vessels were observed.<BR>The vascular structure of the submandibular gland microcirculation after 30 Gy showed leakage of blood components from the vessels and sporadic destruction of the blood vessels as initial changes. In the course of time, the blood vessels became thinner, decreased in number and no vascularization was noted.<BR>From a comparative study of the above results, it was evident that (1) dose-dependent regressive changes with time are seen in the submandibular gland tissue with no sign of recovery when the submandibular, glands are irradiated with X-rays at a dose of at least 10 Gy, and (2) there is a close correlation between the degree of destruction of the microcirculatory system and the decrease in tissue blood flow. Therefore, if the degree of damage of the submandibular gland tissue is determined by measurement of the tissue blood flow in the submandibular glands, this should be effective for the improvement and maintenance of the oral cavity environment toprevent rampant caries.
- 社団法人 日本口腔外科学会の論文
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