骨形成因子によるイヌ人工的顎裂部骨架橋形成に関する実験的研究

概要

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To investigate the feasibility of clinically using bone morphogenetic protein (BMP), BMP was implanted into artificial alveolar clefts of adult mongrel dogs. The crude BMP was obtained from bovine bone matrix. Bovine atherocollagen was also implanted into the clefts as control. The dogs were periodically examined by radiography. Four months after implantation, plaster study models of the maxillary arch were taken. The dogs were then killed and the specimens were examined histologically and radiographically. Moiretopography of the study models was analyzed to examine improvement in the alveolar defect. The results demonstrated that bone bridge formation was radiographically evident in the implanted site 3 months after implantation. At 4 months after implantation, new bone formation rimmed by osteoblasts was microscopically observed among the mature bone. Study model analysis by moiretopography suggested that the form of the alveolar ridges receiving BMP implants was significantly improved. These results indicate that the implantation of BMP is a useful procedure for the treatment of alveolar clefts.