インターフェロンの局所投与が有効であった悪性黒色腫の1症例

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A malignant melanoma of the oral cavity which was not so responsive to DAV therapy and Liniac radiotherapy but succesfully responded to local injection of interferon-β is reported. A 67-year-old male came to our department complaining of a painful tumor on the palate on November 1, 1989. Initial examination showed a diffuse melanoma on the upper alveolar gum, hard palate, and soft palate which infiltrated to the cheek and upper lip mucosa. Signs of metastasis to the regional lymph nodes were not evident. Although he was treated with chemotherapy (DTIC, ACNU and VCR) and highdose intermittent radiotherapy, the tumor did not disappear. We therefore tried local injection of interferon-β(100-300×104 IU/day, 3-5 times/week). The tumor disappeared completely after 6 months. However, a metastatic lymph node (30 mm) of the submandibular region was detected and neck dissection was carried out. Three years after his first visit, neither local recurrence nor distant metastasis have been clinically detected.
社団法人日本口腔外科学会の論文