In vitro and in vivo degradation of human dental plaque by mutanase.

概要

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In vitro and in vivo effects of mutanase on the release of reducing sugar from human dental plaque were examined. In vitro, release of reducing sugar was detected with 2.8 units of mutanase, and linearly increased to about 11 units. In vivo, after rinsing for 1 minute with mouthwash containing 11 units of mutanase, the amount of released reducing sugar was significantly higher (p<0.01) than that after rinsing with placebo (heatinactivated mutanase solution). However, mouthwash containing 2.8 units of mutanase had no effect. These results suggest that mutanase degrades human dental plaque, and that the lowest clinically effective level of mutanase is between 2.8 and 11 units.
有限責任中間法人日本口腔衛生学会の論文