鉛 亜鉛同時投与によるラット硬組織中鉛濃度の変動について
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In order to study the effect of dietary lead in rats, a study was performed to evaluate changes in lead and zinc concentration in hard tissues, as well as changes in aminolevulinic acid dehydratase (ALA-D activity), a major parameter of lead intoxication.<BR>Rats were given 1m mol/kg of lead or 1m mol/kg each of lead and zinc for 3 consecutive weeks after a conditioning period of 1 week at 3 weeks of age, and the effect of zinc on lead concentration was evaluated.<BR>Body weight was significantly decreased in the lead group compared to the controls (P<0.05). Kidney weight tended to decrease in the lead + zinc group compared to the lead group.<BR>Lead concentrations in femur, mandible, and molar dentin were lower in the lead + zinc group than in the lead group (P<0.05), and the opposite was true for zinc concentration (P<0.001).<BR>As in hard tissues, lead concentrations in the liver and kidneys were much lower in the lead + zinc group than in the lead group (P<0.01 and P<0.001, respectively). However, zinc concentration was not affected by administration of zinc in the lead + zinc group. Blood ALA-D activity was lower in the lead group than in the controls (P<0.01). A slight recovery was seen in ALA-D activity after simultaneous adiministration of lead and zinc but the activity level remained below the control level. Lead concentrations in the femur and mandible and those in molar dentin and enamel were singnificantly correlated in all experimental groups.<BR>These findings suggest that lead concentrations in hard tissues of rats can be decreased to some extent with concomitant lead and zinc administration.
- 有限責任中間法人 日本口腔衛生学会の論文
有限責任中間法人 日本口腔衛生学会 | 論文
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