Mutanase及びDextranaseのう蝕予防効果に関する研究-2-ラット実験う蝕について
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The preventive effect of mutanase (from <I>Pseudomonas</I> sp.) and dextranase (from Corynebacteriumpseudodiphtheriticum) on the formation and progress of experimental dental caries in rats was examined.<BR>When the enzymes were given immediately after the infection with <I>Streptococcus mutans</I> OMZ 176, the statistical caries score indicated that both enzymes had a significant preventive effect on the formation of dental caries in rats. The effect was especially pronounced in a combination treatment (1 unit each enzyme/g diet or m<I>l</I> drinking water). In observations of the tooth surfaces under a scanning electron microscope, thick plaque adhered to the enamel and the dentin of the control group, but the plaque could not be observed and the fine structure of the enamel and the dentin of the treated group (with mutanase 1 unit+dextranase 1 unit) were normal.<BR>After experimental dental caries caused by infection with <I>S. mutans</I> OMZ 176 and then by Diet 2000, the rats were treated with a single or a combination dose of the two enzymes. The combination of the two enzymes (1 unit each enzyme/g diet or m<I>l</I> drinking water) was the most effective for the inhibition of caries progression.<BR>From these results, the two enzymes, which have different substrate specificity, have a synergistically preventive effect on the formation and progress of dental caries in rats, suggesting the possibility of using dextranase in combination with mutanase for the prevention of human dental caries.
- 有限責任中間法人 日本口腔衛生学会の論文
有限責任中間法人 日本口腔衛生学会 | 論文
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