Cariogenicity of sorbose as a substrate.
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概要
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Sorbose is a 2-ketohexose, differing from fructose in configuration at C-3 and C-4. It is obtained through a cultivation of sorbitol and <I>Gluconobacter (Acetobacter) suboxydans</I>. The sugar is about 80-90% as sweet as sucrose and is also non-hygroscopic. The effect of sorbose on the cariogenicity of mutans streptococci (serotype <I>a-h</I>) and certain oral microorganisms was studied. Sorbose was not utilized as a substrate for the growth, lactic acid production, and plaque formation of mutans streptococci (serotype <I>a-h</I>). It did not serve as a substrate for cellular aggregation of mutans streptococci and was not utilized in water-insoluble glucan synthesis and cellular adherence by glucosyltransferase from <I>Streptococcus mutans</I> PS-14 (<I>c</I>) or <I>S. sobrinus</I> 6715 (<I>g</I>). Sorbose was also not utilized for the growth and lactic acid production of certain oral microorganisms although some growth was seen with <I>Lactobacillus casei</I> and <I>L. acidophilus.</I> Two groups of SPF SD rats infected with S. mutans PS-14 were fed with a diet containing 30% sorbose and 30% sucrose for 58 days. A significantly (<I>p</I><0.01) lower caries score (mean±SE; 17.5±2.0) was obtained in the rats fed with a diet containing 30% sorbose than in the rats fed with a diet containing 30% sucrose (82.1±4.4). The caries inhibition rate was 78.7%.
- 有限責任中間法人 日本口腔衛生学会の論文
有限責任中間法人 日本口腔衛生学会 | 論文
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