Successful Treatment of Immunoglobulin D Myeloma by Bortezomib and Dexamethasone Therapy
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概要
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Immunoglobulin D (IgD) myeloma is a rare subtype and it is widely accepted as an aggressive disease. Here, we report a 66-year-old woman with IgD myeloma who had anemia, lumbago, multiple osteolytic lesions and hypercalcemia. The patient refused a blood transfusion because of her beliefs, so we administered bortezomib and dexamethasone (BD) after high-dose dexamethasone therapy. Marked improvement of anemia and elevated serum alkaline phosphatase levels was recognized. After 5 cycles of BD therapy, the patient achieved a stringent complete response according to International Myeloma Working Group Response Criteria. BD therapy might be a feasible and useful treatment option for IgD myeloma.
著者
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SEKIGUCHI Naohiro
Hematology and Stem Cell Transplantation Division, National Cancer Center Hospital
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Miwa Akiyoshi
Hematology
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Sekiguchi Naohiro
Hematology Division, National Hospital Organization Disaster Medical Center, Japan
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Takezako Naoki
Hematology Division, National Hospital Organization Disaster Medical Center, Japan
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Nagata Akihisa
Hematology Division, National Hospital Organization Disaster Medical Center, Japan
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Wagatsuma Miyuki
Pathology Division, National Hospital Organization Disaster Medical Center, Japan
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Noto Satoshi
Hematology Division, National Hospital Organization Disaster Medical Center, Japan
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Yamada Kazuaki
Pathology Division, National Hospital Organization Disaster Medical Center, Japan
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Miwa Akiyoshi
Hematology Division, National Center for Global Health and Medicine, Japan
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