Novel 4,5-Dihydro-thiazinogeldanamycin in a gdmP Mutant Strain of Streptomyces hygroscopicus 17997

スポンサーリンク

概要

• 論文の詳細を見る

• Novel geldanamycin derivative, 4,5-dihydro-thiazinogeldanamycin (3), was characterized from the gdmP mutant in Streptomyces hygroscopicus 17997, besides expected 4,5-dihydro-geldanamycin (2). The presence of this compound would suggest an unknown post-PKS modification in geldanamycin biosynthesis. Compound 3 exhibited moderate anti-HSV-1-virus activity and higher water solubility than geldanamycin (1). Cysteine served as a precursor to synthesize 3, whose formation required obligatory enzymatic assistance.

• 社団法人 日本農芸化学会の論文

著者

• LIN Ling

  Northeast Agricultural University

• NI SiYang

  Key Lab of Biotechnology of Antibiotics, Ministry of Health, Institute of Medicinal Biotechnology, C

• WU LinZhuan

  Key Lab of Biotechnology of Antibiotics, Ministry of Health, Institute of Medicinal Biotechnology, C

• WANG YiGuang

  Key Lab of Biotechnology of Antibiotics, Ministry of Health, Institute of Medicinal Biotechnology, C

• WANG YuCheng

  Key Lab of Biotechnology of Antibiotics, Ministry of Health, Institute of Medicinal Biotechnology, C

• TAO PeiZhen

  Key Lab of Biotechnology of Antibiotics, Ministry of Health, Institute of Medicinal Biotechnology, C

• HE WeiQing

  Key Lab of Biotechnology of Antibiotics, Ministry of Health, Institute of Medicinal Biotechnology, C

• WANG XiangJing

  Northeast Agricultural University

関連論文

• Novel 4,5-Dihydro-thiazinogeldanamycin in a gdmP Mutant Strain of Streptomyces hygroscopicus 17997
• Novel 4,5-Dihydro-thiazinogeldanamycin in a gdmP Mutant Strain of Streptomyces hygroscopicus 17997

スポンサーリンク