Novel 4,5-Dihydro-thiazinogeldanamycin in a gdmP Mutant Strain of Streptomyces hygroscopicus 17997
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概要
- 論文の詳細を見る
Novel geldanamycin derivative, 4,5-dihydro-thiazinogeldanamycin (3), was characterized from the gdmP mutant in Streptomyces hygroscopicus 17997, besides expected 4,5-dihydro-geldanamycin (2). The presence of this compound would suggest an unknown post-PKS modification in geldanamycin biosynthesis. Compound 3 exhibited moderate anti-HSV-1-virus activity and higher water solubility than geldanamycin (1). Cysteine served as a precursor to synthesize 3, whose formation required obligatory enzymatic assistance.
- 2011-10-23
著者
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Lin Ling
College Of Plant Pathology Nanjing Agricultural University
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LIN Ling
Northeast Agricultural University
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NI SiYang
Key Lab of Biotechnology of Antibiotics, Ministry of Health, Institute of Medicinal Biotechnology, C
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TAO PeiZhen
Key Lab of Biotechnology of Antibiotics, Ministry of Health, Institute of Medicinal Biotechnology, C
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WANG XiangJing
Northeast Agricultural University
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He Weiqing
Key Lab Of Biotechnology Of Antibiotics Ministry Of Health Institute Of Medicinal Biotechnology Peki
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Wang Yucheng
Key Lab Of Biotechnology Of Antibiotics Ministry Of Health Institute Of Medicinal Biotechnology Peki
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Wang Yiguang
Key Lab Of Biotechnology Of Antibiotics Ministry Of Health Institute Of Medicinal Biotechnology Peki
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Wang Yiguang
Key Lab Of Biotechnology Of Antibiotics Ministry Of Health Inst. Of Medicinal Biotechnology Cams &am
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He Weiqing
Key Lab Of Biotechnology Of Antibiotics Ministry Of Health Inst. Of Medicinal Biotechnology Cams &am
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Wu Linzhuan
Key Lab Of Biotechnology Of Antibiotics Ministry Of Health Institute Of Medicinal Biotechnology
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Tao Peizhen
Key Lab Of Biotechnology Of Antibiotics Ministry Of Health Institute Of Medicinal Biotechnology
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Wang Yucheng
Key Lab Of Biotechnology Of Antibiotics Ministry Of Health Institute Of Medicinal Biotechnology
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Ni Siyang
Key Lab Of Biotechnology Of Antibiotics Ministry Of Health Institute Of Medicinal Biotechnology
関連論文
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- Novel 4,5-Dihydro-thiazinogeldanamycin in a gdmP Mutant Strain of Streptomyces hygroscopicus 17997
- Novel 4,5-Dihydro-thiazinogeldanamycin in a gdmP Mutant Strain of Streptomyces hygroscopicus 17997
- A New Post-PKS Modification Process in the Carbamoyltransferase Gene Inactivation Strain of Streptomyces hygroscopicus 17997
- A novel zinc-finger-like gene from Tamarix hispida is involved in salt and osmotic tolerance
- A pair of sulfur-containing geldanamycin analogs, 19-S-methylgeldanamycin and 4,5-dihydro-19-S-methylgeldanamycin, from Streptomyces hygroscopicus 17997
- 17-O-demethylreblastatin, a subnormal intermediate in geldanamycin biosynthesis
- 7-O-descarbamoyl-7-hydroxygeldanamycin, a minor component from the gdmN disruption mutant of Streptomyces hygroscopicus 17997