食品中のアンジオテンシン : 変換酵素阻害能について

概要

論文の詳細を見る
Angiotensin I-converting enzyme (ACE) is an exopeptidase related to the blood pressure control system. The enzyme converts inactive decapeptide angiotensin I to potent vasoconstrictive octapeptide angiotensin II and also degradates vasodepressive nonapeptide bradykinin. It has become known in recent years that some specific inhibitors, such as SQ-14, 225 (captopril) of the enzyme, reduce blood pressure. In this paper, the inhibiting abilities of 117 kinds of foods including Chinese medicals (herb medicals) and vasodepressive medicals were pre-liminarily tested. Samples were assayed by the modified Cushman method using hog renal ACE. Fifty kinds of samples, such as soya-bean foods, teas, shell fishes, fruits and buckwheat (soba) in-hibited the enzyme consciously. Their inhibitory activities were found in hot water extracts after dialysis, suggesting that the active principle was a heat stable and low molecular weight substance.
社団法人日本農芸化学会の論文