Bacillus Megateriumによるステロイドの20-カルボニル基の還元

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During the studies of 15 β-hydroxylation of steroids with Bacillus megaterium which has been reported to introduce a 15 β-hydroxyl group into the steroid nucleus, we found that B. megaterium IAM 1166 was capable of reducing 20-carbonyl group of some steroids of pregnane series. This strain converted 17 α-hydroxyprogesterone into 17 α, 20 α-dihydroxy-4-pregnen-3-one (20%) and Reichsteins Compound S into 17 α, 20 β, 21-trihydroxy-4-pregnen-3-one (20%). But progesterone, desoxycorticosterone and 4-androstene-3, 17-dione were not converted.
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