東京医科歯科大学皮膚科における悪性黒色腫症例の統計的観察

概要

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A statistical study of 43 patients with malignant melanoma treated at Department of Dermatology, Tokyo Medical and Dental University during 1959 to 1991 was reported. We have confirmed TNM classificaton, Clark's level, tumor thickness and prophylactic lymph node dissection as siginificant factors to decide prognosis of malignant melanma.1) Our cases consisted of 49% of acral lentiginous melanoma, 14% of superficial spreading melanoma, 14% of nodular melanoma, 2% of lentigo maligna melanoma, 5% of unknown cases. Our cases consisted of 16% of Stage I cases, 30% of stage III cases, 19% of stage IV cases, 5% of unknown cases.2) The five years survival rates of each stage were as follows: stage I 100%, stage II 92%, tage III 53%, stage IV 0%. Prophylactic lymph node dessection of cases of stage III showed improvement of prognosis.3) Analysis of 12 patients who had prophylactic lymph node dissection showed that three patients had histological regional metastasis whose thickness was over 1.5mm and levels was IV or V of the primary lesion. Prophylatic lymph node dessection appeared to necessary and useful in the patients with primary lesion having over 1.5mm thickness and IV or V level.