右肘皮下に生じたメルケル細胞癌の1例

概要

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A 58-year-old Japanese female with Merkel cell carcinoma is described. She noted her subcutaneous nodule on her right elbow about two years before visiting our dermatological out patient clinic. Light microscopy revealed that the tumor cells showed a trabecullar organoid growth pattern and were localized mainly in subcutane ous tissues. The individual cells were round and uniform in size and shape. Immunocytochemically, tumor cells were positiveiy stained with rabbit anti-neuron specific enolase antibody as well as RGE53 and HKN-4 anti-keratin monoclonal antibodies. Electron microscopy demonstrated dense core granules and intermediate filaments in the tumor cells. From the features mentioned adove, we diagnosed her subcutaneous tumor as Merkel cell carcinoma. Management; she underwent the wide resection of the tumor and dissection of the right axillary lymphnodes. In addition she received radiotherapy for primary lesion and chemotherapy as follows; CDDP+ ADM+VCR+ETP.