Fatty Acid Composition of Serum Lipid in Liver Diseases

概要

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The fatty acid composition of serum lipid in various liver diseases was analyzed by gasliquid chromatography and compared with that of normal and hypercholesterolemia.In liver diseases, the change of fatty acid composition was most remarkable in cholesterolester fraction, less marked in triglyceride and phospholipid fraction, and least in free fatty acid fraction.In all lipid fractions examined, percentages of palmitate, palmitoleate and oleate were increased, and arachidonate was decreased in liver diseases. Linleate was markedly decreased in cholesterol-ester fraction and slightly in triglyceride and free fatty acid fraction.Amoung various liver diseases, the change of fatty acid composotion was most conspicuous in liver cirrhosis, hepatoma and fatty liver.Analysis of serum fatty acid composition can be utilized as an indicator of liver dysfunction.The mechanism of the change of fatty acid composition in liver diseases was discussed in comparison to the results of plasma fatty acid composition of ethionine treated rats.
財団法人日本消化器病学会の論文