Clinicopathologic Study on Hepatic Fibrosis
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概要
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Fortysix cases of chronic alcoholics consuming daily more than 110g of alcohol were studied histologically and histochemically on liver biopsy specimens. At the same time, 46 of nonalcoholics, in which the clinical data strongly suggested to be viral in origin were also studied comparing with alcoholic group.In alcoholics, variant extents of necrosis were recognized in 58% in parenchyma and 69% around portal area, associated with mild or slight infiltrates of mononuclear cell mixing polymorphonulcear leukocytes. Forty in 46 had a mature collagenous fibrils in their connective tissue, accompanied with unmature newly formed fibers. The accumulation of histochemically demonstrable acid mucopolysaccharides was recognized in portal area, increasing connective tissue fibers, perisinusoidal space and especially necrotic areas. These necrotic areas assumed to play a leading role in fibrogenesis of livers in alcoholics. Alcoholic hyaline could be demonstrated in 2 cases. Infiltration with fat was mild in 18 and moderate in 3 cases.In nonalcoholic group, 39 of intralobular and 32 of periportal necrosis were seen with mononuclear cell infiltration. Twentyfour had mature collagenous fibers with unmature fiblils concomitantly. Six showed unmature, young fiblils only, though they had alreadly pseudolobular formation. Acid mucopolysaccharides were demonstrates in portal area, necrosis in periportal area and increased connective tissue fibers, but they all showed poor accmulation in contrast with alcoholic group.
- 財団法人 日本消化器病学会の論文