肝疾患における血清アデノシンデアミナーゼ活性の臨床的意義

概要

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Serum adenosine deaminase (AD) activity was measured in 41 cases of acute liver diseases and 363 cases of chronic liver diseases. Following results were obtained. (1) In acute hepatitis (AH), serum AD levels were high in type A, type non-A, non-B (NANB) prolonged, type B, type NANB nonprolonged, in that order. (2) Serum AD levels were not correlated with serum GPT levels except type A hepatitis. Most of type NANB patients whose AD reached higher levels in the convalescent stage showed prolongation of the liver dysfunction. (3) Serum AD levels in liver cirrhosis (LC) were significantly higher than chronic hepatitis (CH). (4) A frequency of markedly elevated adenosine deaminase level over than normal mean value+8SD was high in LC type NANB, LC type B, CH type NANB, CH type B, in that order. (5) There were no correlations between serum AD and GPT in CH, and serum AD and GOT in LC. Serum AD levels in most of type NANB CH and LC patients who had normal transaminase levels showed to be high enough and did not show a large fluctuation in their clinical courses. These results indicated that the measurement of serum AD activity is not only useful in foreseeing the prognosis of AH type NANB, and in screaning to detect subclinical patients with chronic liver diseases, especially type NANB diseases.
財団法人日本消化器病学会の論文