Pathological study on the histogenesis of the gallbladder carcinoma.:Significance of Intestinal Metaplasia, Adenoma, and Dysplasia

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Thity-eight gallbladder carcinomas were classified into four types on the basis of gross appearances, that is, type A: pedunculated polyp type, type B: sessile polypoid type, type C: superficially spreading type, type D: diffuse infiltrating type.The significance of intestinal metaplasia, adenoma, and dysplasia for the evolution of gallbladder carcinoma was investiaged in each type. As a result, three modes of histogenesis of gallbladder carcinomas were suggested. In the first mode, carcinomas showing the gross appearence of type A, arise from areas of adenoma, where intestinal metaplastic changes are unusually observed. In the second mode, islands of intestinal metaplasia, or dysplastic areas accompanied with intestinal metaplasia make a considerable role in the histogenesis of carcinomas of type B and C. In the third mode, dysplastic areas which originate in the mucosa with severe chronic cholecystitis may contribute to the inception of carcinomas of type D.
財団法人日本消化器病学会の論文