Experimental study of intrinsic endotoxemia in liver cirrhotic rats.

概要

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Experimental liver cirrhosis was induced in Donryu test rats by intraperitoneal administration of thioacetamide.Endotoxin (ET) quantitative analysis were then conducted of blood from the inferior vena cava and portal vein and lymph from the thoracic duct.There was no significant difference in ET levels of inferior vena cava blood, portal vein blood and thoracic duct lymph, either in the group with cirrhosis of the liver or in the control group.ET levels were higher in the group with cirrhosis of the liver than in the control group, and the physiological effects of the operations led to greater elevation in the ET levels in the group with cirrhosis of the liver than in the control group.Plasma endotoxin inactivating activity in the group with cirrhosis of the liver was lower than that in the control group.It is proposed that the decreased plasma endotoxin inactivating activity in the group with cirrhosis of the liver is one important cause of intrinsic endotoxemia.
財団法人日本消化器病学会の論文