Decreased insulin bindings to erythrocytes in acute hepatitis. Correlation with the degree of hepatic damage.:Correlation with the Degree of Hepatic Damage

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概要

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• In order to elucidate the changes of insulin receptor in acute hepatitis, 125I-insulin binding to erythrocytes was studied in nineteen patients with acute hepatitis and the binding data were analyzed in relation to basal insulin levels and the degree of hepatic damage.Specific insulin binding to erythrocytes was significantly decreased in patients with acute hepatitis as compared with that in normal controls. Scatchard analysis suggested that this decreased binding was secondary to a decrease in the receptor number per cell. There was a significant correlation between specific insulin binding and Hepaplastin test values. However, no correlation was found between specific binding and basal insulin levels.These data suggest that the decreased insulin binding to erythrocytes in acute hepatitis may not be caused by down regulation commonly seen in the state of hyperinsulinemia, but by some different mechanism(s) intimately related to the degree of hepatic damage.

• 財団法人 日本消化器病学会の論文

著者

• 西村 泰行

  金沢大学医学部第1内科

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• Decreased insulin bindings to erythrocytes in acute hepatitis. Correlation with the degree of hepatic damage.:Correlation with the Degree of Hepatic Damage

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