Immunohistochemical study of secretory immunoglobulin a in Crohn's disease.

概要

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To investigate possible mechanisms of elevation of serum secretory immunoglobulin A (sIgA) level in active Crohn's disease, colonic specimens were obtained from 7 patients with active Crohn's disease and were applied to immunohistochemical study of immunoglobulin A (IgA) and secretory component (SC). Serum level of sIgA and the number of IgA containing cells in the lamina propria were significantly increased in Crohn's disease than in control subjects. Light microscopic immunohistochemistry showed that staining intensity of SC was increased in the whole mucosal epithelium, particularly at the luminal surface of the mucosa in Crohn's disease compared with the mucosal epithelium of control subjects. Electoron microscopic immunohistochemistry demonstrated that reaction products of SC were observed in the interstitium of lamina propria in Crohn's disease, possibly released from the basal plasma membrane of the epithelial cells. These findings were frequently recognized in Crohn's disease, but rarely in control subjects. These results suggested the mecanisms of elevated serum sIgA in active Crohn's disease might be derived from excessively produced sIgA in the colonic mucosa.
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