Study on increased immunoglobulin A in alcoholic liver disease. Analysis of serum secretory and dimeric IgA and IgA containing cells in the lamina propria of the colon.:Analysis of serum secretory and dimeric IgA and IgA containing cells in the lamina pro

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To investigate the possible mechanislns of elevation of serum IgA level in alcoholic liver disease (ALD), serum secretory IgA (SIgA) and dimeric IgA (D-IgA) were studied in 74 cases with various types of ALD. SIgA and D-IgA were significantly increased in ALD compared with control subjects, and there was a significant correlation between serum IgA and D-IgA, SIgA and D-IgA (%). SIgA level was significantly correlated with values of sGOT, sGPT and/or γ-GTP. In the immunohistochemical study of IgA, the number of IgA containing cells in the lamima propria of colon was significantly increased in the elevated cases of serum IgA level in ALD, Moreover in ALD, D-IgA level was significantly correlated with the number of IgA containing cells in the lamina propria. These results conclude that the mechanism of elevated serum IgA in ALD is partly derived from excessively produced D-IgA in the Colonic mulcosa.