Lectin staining on carcinoma of gallbladder and mucosa of chronic cholecystitis.
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In order to clarify the cytoplasmic character in carcinoma of gallbladder, dysplastic epithelium, and mucosa of chronic cholecystitis, totally 60 cases of surgically resected gallbladders (29; carcinomas of gallbladder, 31; chronic cholecystitis) were examined with lectins (Ulex europaeus agglutinin-1 (UEA-1) and Peanut lection (PNA)) and Carcinoembryonic Antigen (CEA).In chronic cholecystitis both covering epithelium and Rokitansky-Aschoff sinuses were stained well with UEA-1, but, neither covering epithelium nor Rokitansky-Aschoff sinuses were stained with PNA or with CEA. Pseudo-pyloric glands were stained with UEA-1 and with PNA, but they were not stained with CEA. Hyperplastic epithelium in chronic cholecystitis was stained with UEA-1 and with PNA in half of cases examined. However, the hyperplastic epithelium was not stained with CEA.Respectively, in most cases of carcinoma of the gallbladder, carcinoma cells were stained with UEA-1, as well as covering epithelium in chronic cholecystitis. Carcinoma cells were also stained with PNA and CEA, though covering epithelium in chronic cholecystitis was stained neither with PNA nor with CEA. In carcinoma, the binding sites of UEA-1 or PNA were not always consistent with positive sites for CEA. In contrast to well staining in the covering epithelium, dysplastic epithelium next to carcinoma was stained negative or little on cell apex with UEA-1, showing the loss of fucosyl glycoproteins, especially of blood group H (O) substance. The dysplastic epithelium was stained weakly positive on cell apex with PNA and with CEA, and weakly positive in cytoplasm with PNA.These findings suggest that change of UEA-1 binding glycoproteins and PNA binding glycoproteins is induced in the process of canceration. And in comparison with the findings of CEA which appeared especially on carcinoma, the localization of the glycoproteins differs even among morphologically similar cells.
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- Lectin staining on carcinoma of gallbladder and mucosa of chronic cholecystitis.