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To study the effect of taurocholate on sulfobromophthalein (BSP) excretion in the rats with relieved biliary obstruction, 42 Wistar rats were divided into two groups; 30 jaundiced rats were prepared ligating the common bile duct and relieving the obstruction 48 hours prior to the study, 12 control rats were prepared with a biliary fistula formation.The hepatic uptake and biliary transport of BSP was studied in 6 ras of each groups by determining the BSP transfer rate constants (a-value, hepatic BSP uptake; b-value, reflux from liver to plasma; h-value, elimination of BSP into bile), the transport maximum and the relative storage capacity. Similar studies were carried out in 6 rats of each groups by simultaneous injection of sodium taurocholate with BSP to evaluate the influence of bile salt on BSP transport into bile.The results were as follows:a) Subsequent increase in bile acid excretion after biliary decompression was significantly suppressed in the jaundiced rats as compared to the control rats.b) Biliary transport of BSP was significantly suppressed shortly after biliary decompression indicating either the secondary intrahepatic cholestasis or the insufficiency of organic anion excretion.c) Administration of sodium taurocholate markedly increased BSP transport into bile, whereas equal amounts of sodium taurocholate injection produced cholestatic effect on the control rats.In conclusion, effective elimination of plasma bilirubin after biliary decompression might be achieved by supplemental administration of bile salts whereby facilitating canalicular organic anion transport, provided that bile acid clearance remains intact.

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