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Study was made on cats with total gastric fistulae to elucidate the interaction of three receptors on parietal cells by nerve stimulation with 2-Deoxy-D-Glucose (2DG) using cimetidine (H2 receptor antagonist) and pirenzepine (acetylcholine muscarin receptor antagonist). The cimetidine inhibited MAO to 50 percent (ID50 cimetidine dose) after histamine stimulation was 0.53mg/kg, and the pirenzepine dose to inhibit MAO to 50 percent (ID50 pirenzepine dose) after bethanchol stimulation was 0.45mg/kg. The author determined the dose of acid secretion when ID50 cimetidine dose and ID50 pirenzepine dose were administered independently and in combination under 2-DG stimulation, and calculated the ratio of parietal cell acetylcholine, gastrin and histamine receptor involvement in acid secretion. Results indicated the ratio of the three receptors to be 1:4:3.
財団法人日本消化器病学会の論文