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Fifty male Wistar rats were divided into five groups of each 10 rats and operated in order to examine the effects of intraluminal pressure and devascularization in pathogenesis of ischemic colitis.In group 1, marginal arteries of the left colon were ligated in two points at intervals of 2cm.In group 2, rectum was completely obstructed by ligation.In group 3, were operated with combination of both precedures.In group 4, 30mg sodium picosulfate (laxoberon) was administered orally for 2 days after ligation of marginal artery.In group 5, the same laxative was only administered orally for 2 days without operation.The animals were sacrificed 72 hours after the surgery and were examined on morphological changes of the colon macroscopically and histologically.The activities of serum GPT, LDH and Al-pase were also examined in each group.The experiments gave the following results -2 rats of group 1 (20%), one rat of group 2(10%), 8 rats of group 3(80%) and 2 rats of group 4(20%) showed ischemic lesions on the left colonic mucosa.Histologically, the observed ischemic changes consisted of necroses in several degrees from mucosa to muscularis propria, erosions or ulcerations.The incidence of ischemic lesion in group 3 was significantly higher than in other groups.It may be concluded that increasing intraluminal pressure additional to devascularization of colonic wall, is considered to play an important part in pathogenesis of ischemic colitis.
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