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Localization of CEA has been examined in 21 cases (22 lesions) of atypical epithelium and 24 cases (25 lesions) of well-differentiated early cancer, Type IIa, of the stomach using immunoperoxidase technique. 19 of 22 lesions (86.4%) of atypical epithelium were negative to CEA, and a small portion of 3 lesions showed a weak positive reaction. Among the 25 lesions of well-differentiated early cancer, a strong positive reaction to CEA was observed throughout 20 lesions (80.0). A weak to moderate positive reaction to CEA was observed in epithelium with intestinal metaplasia surrounding both lesions.Such a remarkable difference of CEA localization between lesions of atypical epithelium and well-differentiated early cancer suggests that the two lesions may be different from each other biologically. Furthermore, it is presumable that atypical epithelium may be not premalignant lesion. It is considered that examination of CEA localization may be helpful for differentiation of atypical epithelium from well-differentiated early cancer, in most cases.
財団法人日本消化器病学会の論文