:Changes on Blood Flow Influence of HCl Intraduodenal Administration

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In order to research on the responce of duodenum to acid, we observed the changes of duodenal blood flow by HCl intraduodenal continuous administration. Body weight 10-20kg dogs were fasted for 24 hours prior to surgery, but water was provided. Under pentobarbital anesthesia set the probe of electromagnetic flow meter (or doppler flow meter) on the duodenal branch of the Arteria pancreatico-duodenalis. Intraduodenal administration of HCl (10ml/min, ) was performed by stomach tube. By pH 1.0 HCl intraduodenal administration, duodenal blood flow was increased. And submucosal blood flow of duodenum, measured by 133Xe-clearance method, was also increased. But, inspite of continuous pH 1.0 HCl intraduodenal pouring, an increase of duodenal blood flow was not continuous. The duration was about 25 minutes. An increase of duodenal blood flow was more predominantly by pH 1.0 HCl than pH 3.0 HCl intraduodenal pouring. But, an increase of blood flow by pH 1.0 HCl following pH 3.0 HCl was not significant. So we thought that an increase of the duodenal blood flow by HCl was caused not only acidity of HCl, but also difference of acidity.
財団法人日本消化器病学会の論文