タイトル無し

概要

論文の詳細を見る
The First Department of Internal Medicine, Kyoto Prefectural University of Medicine For the quantitative measurement of pancreatic oncofetal antigen (POA), an enzyme immunoassay for POA based on the sandwich method has been developed. Using IgG fraction of anti-POA serum, antibody coupled beads and enzyme (peroxidase) labeled antibody were prepared. The dilution of fetal pancreas homogenate was defined as standard POA, and standard curve was made for the estimation of POA level in each sample. The enzyme immunoassay employed for POA showed satisfactory results in clinical application. And significantly elevated serum POA levels were found in patients with pancreatic cancer, compared with those in other miscellaneous diseases or in normal subjects, suggesting that the measurement of POA in serum may be useful in the diagnosis of pancreatic cancer. Serum POA level has changed being accompanied with the progress and the removal of the cancer of the pancreas, and therefore the assay of serum POA may be also useful in monitoring the course of the disease.
財団法人日本消化器病学会の論文