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To search on the genesis of gastric ulcer, histochemical and histological studies were performed on stress ulcer in water immersion restrained rat and the contents of cyclic nucleotides in gastric mucosa, muscle layer and ulcers were measured, using radioimmunoassay combined with Lowry's microassay method modified by Numano.All rats restrained in water immersion exhibited spotty and/or linear erosions in their gastric wall. Histological studies revealed these ulcers occur at the folds of the gastric mucosa and developed concentrically towards the muscle layers. Ulcers revealed no activities of LDH, SDH, however, their activates in gastric mucosa neighbored to ulcer showed the same activities as those in normal mucosa, that is, positive and negative activities were sharply or linearly differentiated at the boundary of ulcers. Alkaline phosphatase activity was demonstrated equally in the deeper layer of gastric mucosa.The contents of cyclic AMP on the non-ulcer lesion of the mucosa of stress rat revealed a statistical significant high levels as compared with those in normal control (p<0.01). On the other hand, the contents of cyclic GMP in ulcer lesions revealed a significant high levels compared with those in control mucosa. The content of cyclic AMP in muscle layer of stress rat was statistically significantly low as compared with those in control muscle.These data suggest that stress ulcer results in the destruction of mucosal barrier, and that the high levels of cyclic AMP in gastric mucosa of stress rat may reflect the increased metabolism in mucosal cells to secrate some substances cause ulcers, on which the further studies should be required.
財団法人日本消化器病学会の論文

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