A STUDY OF THE CELL-MEDIATED IMMUNITY IN CHRONIC INFLAMMATORY BOWEL DISEASE: ROLE OF THE ENTEROBACTERIAL COMMON ANTIGEN

概要

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To assess cell-mediated immunity in chronic inflammatory bowel disease, lymphocyte proliferative response to phytohaemagglutinin (PHA) and lipopolysaccharides (LPS) extracted from E. coli 014, 026, 0111 and Vibrio cholerae were measured by lymphocyte transformation test. Lymphocyte proliferative response to PHA in patients with ulcerative colitis did not differ significantly from that in the controls. However, it was significantly depressed in patients with Crohn's disease. This depression disappeared and the response returned to normal level after resection of the involved bowel. Lymphocytes from patients with active ulcerative colitis showed obvious proliferative response to E. coli 014 LPS which is known to contain enterobacterial common antigen (ECA) and to have cross-reactivity to colon antigen, but not to LPS from E. coli 026, 0111, or V. cholerae. In contrast, lymphocytes from patients with Crohn's disease as well as those from healthy controls did not show any proliferative response to all the LPS preparations tested. The proliferative response to 014 LPS seen in lymphocytes of active ulcerative colitis patients was demonstrated to be the response of T lymphocytes. These results suggest that T lymphocytes sensitized to ECA may play an essential role in the pathogenesis of ulcerative colitis.
財団法人日本消化器病学会の論文