AN EXPERIMENTAL STUDY ON THE HISTAMINE METABOLISM UNDER THE HEPATIC DISTURBANCE

概要

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In an attempt to clarify the role of the liver in the histamine metabolism, the changes of the plasma histamine levels in the portal and hepatic venous blood, the number of the tissue mast cells in the liver and the in vitro histamine release in the liver were studied following the administration of either histamine chloride or compound 48/80 into intact and carbon tetrachloride treated dogs.The plasma histamine level of the portal blood was higher than that of the hepatic venous blood in both control and CCl4-treated dogs before the administration of the test drugs. The plasma histamine levels were similar in both control and CCl4-treated dogs after the administration of histamine chloride, while the level in CCl4-treated dogs was higher than that in controls after the administration of compound 48/80.There was no definite change in the number of the tissue mast cells in the liver of both control and experimental dogs.The rate of the release of histamine in the liver, tested in vitro, was much higher in CCl4-treated dogs than in controls.The important role of the liver in the histamine metabolism was indicated by the changes in the plasma histamine levels observed in the present study. Histamine is inactivated in the liver and the hepatic disturbance bring about the acceleration of histamine release.
財団法人日本消化器病学会の論文