RELATIONSHIP BETWEEN BIOCHEMICAL LIVER FUNCTION TESTS:Serum GPT Values and Endocrine-Metabolic Features in Obese Subjects

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76 obese subjects, all of whom were 30 to 50 per cent above ideal body weight, were devided into the cases with normal and abnormal serum GPT values, and compared with the two groups about the fasting levels of serum insulin, blood glucose and serum lipids, and the degree of abnormality of the glucose tolerance tests (OGTT) in both sexes.1) In males 16 in 43 obese subjects had abnormal S-GPT values, and the fasting serum insulin and blood glucose levels of the group with abnormal S-GPT values were significantly higher than those of the group with normal S-GPT. There were no significant differences about the degree of the OGTT and the levels of serum lipids between the both groups with normal and abnormal S-GPT values.2) In females only 2 cases in 33 obese had abnormal S-GPT values.3) In both sexes the S-GPT values proved significantly related to the fasting serum insulin levels, that were lower in females than in males. The non-hyperinsulinism in the female obese may explain that there are few cases with abnormal S-GPT values.
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