CORRELATION BETWEEN BLOOD CEA AND HISTOLOGICAL FINDINGS IN PATIENTS WITH GASTRIC CANCER

概要

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The factors elevating blood CEA levels were examined correlating with the histological findings in 102 cases with gastric cancer. The blood CEA levels showed higher in proportion to the classification of Borrmann's IV, III, II and I type. The positive percent of blood CEA levels in early gastric cancer was 20% regardless of its histological types. In advanced cancer, however, blood CEA levels were influenced by the degree of differentiation, being high in well differentiated types and low in poorly differentiated types. The blood CEA levels became higher as the cancer invaded deeper, but it was not correlated with the presence of metastasis to regional lymph nodes. About the infiltration type (INF), the positive rate of blood CEA became higher in proportion to INF γ, β and α. The positive rate of blood CEA increased according to the progression of the invasion to lymph-vessels and veins. Especially, in the cases of moderately differentiated tubular adenocarcinoma, the blood CEA levels showed high according to vein invasion. Vascular invasion was one of the major factors of CEA passing from the tissue into the blood.