A Clinical and Histological Study of the Gastric Secretion Induced by Gastrin Tetrapeptide:with special reference to caffeine method
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This study is mainly concerned with whether or not there is a relationship between the caffeine and the gastrin (tetragastrin) method and whether the gastric acidity evoked by the latter method is histologically well related to the status of parietal cells.1) The gastric secretion by 4r/kg tetragastrin is significantly higher (P<0.001) than that by the caffeine method, both in acidity and peptic activity.2) Fundamentally there appears to be a similarity between these two methods (r=0.61 P<0.001), however the most remarkable difference is that almost all of the "achylia gastrica" group by caffeine method are raised to the "normoacidity group" by the gastrin method.3) Gastrin is quick in acid stimulation and the time neccessary for clinical examination may be possibly shortened, because there is a good correlation (r=0.94) between the acidity at 30 or 45 minute collection period and the maximum acidity.4) Maximal dose for acid and pepsin secretion is around 4rg/kg, judged from the dose response curve and the degree of acidity induced by that dose is quantitatively related to the number of parietal cells.5) Concerning the differential diagnosis of gastric diseases by acidity, the gastrin method resembles that of caffeine, that is, duodenal ulcer, erosive gastritis and advanced cancer are significantly differentiated, but the clinical importance of the gastrin method should be centered on the functional diagnostic aspect that enables us to guess the histological background of stomach, though our endoscopic examination sometimes fails to do so.
- 財団法人 日本消化器病学会の論文
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- Endoscopic observation on the papilla of Vater
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- A Clinical and Histological Study of the Gastric Secretion Induced by Gastrin Tetrapeptide:with special reference to caffeine method