A Study of the Changes in pH of Gastric Contents during Twenty-Four Hours by Using Radiotelemetering Capsule
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概要
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The purpose of this study is to observe the spontaneous gastric secretion during twentyfour hours and to develop a physiologically rational therapy for peptic ulcer.The changes in pH of the gastric contents during the twenty-four hour period were studied in 100 hospitalized patients including 23 cases of duodenal ulcer and 34 cases of gastric ulcer.In order to apply the study to the practical treatment of duodenal ulcer, the effect of secretin on fasting pH and postprandial pH of the stomach was observed in 9 patients with duodenal ulcer.The results were as follows:1) As for the variation of gastric pH during the twenty-four hours, differences in the patients and differences in the disease were observed.2) The pH curves of the stomach were classified into 5 types. According to this pH pattern classified by the author, the changes in the gastric secretion are easily understood; furthermore this pattern is very convenient to determine the most suitable time to administer medicine to patients.3) As to the lowest pH during the twenty-four hours, there were no differences between duodenal ulcer and gastric ulcer patients, and also there were no differences between ulcer patients and other patients. As to duration of the pH below 2 or above 5, there were some significant differences among them.4) This suggests that one of the most important pathogenesis of duodenal ulcer is the continuous action of high degrees of acidity during the night.Judging from the therapeutic points of view, I have come to the conclusion that we should consider the pH pattern and the duration of high acidity for medical treatment.5) The effects of intramuscular administration of secretin on fasting pH of the stomach was stronger than the effects on postprandial pH. I supporse this fact was caused by the regurgitation of pancreatic juice. I believe we can use synthetic secretin in the treatment of peptic ulcer.
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関連論文
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- A Study of the Changes in pH of Gastric Contents during Twenty-Four Hours by Using Radiotelemetering Capsule