Serotonin (5-HT). Histamine Release and Hemodynamics following Instillation of hypertonic Glucose into proximal small Intestine before and after Vagotomy in Dog

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In 11 dogs with intact vagus nerves, the administration of hypertonic glucose solution into proximal small intestine resulted in significant decrease of the superior mesenteric arterial blood flow, significant increase of the carotic arterial blood flow, rise of both plasma 5-HT and histamine levels in portal vein, and almost all of 5-HT releasa from enterochromaffin cells. In 15 dogs in which both truncal vagi were severed, the administration of hypertonic glucose solution into proximal small intestine resulted in significant increase of the superior mesenteric arterial blood flow, significant decrease of the carotic arterial blood flow, significant rise of plasma 5-HT levels in portal vein, and a imcomplete release of 5-HT from the enterochromaffin cells. In 15 dogs in which both gastric vagi were severed, the administration of hypertonic glucose solution into proximal small intestine, resulted in slight decrease of the superior mesenteric arterial blood flow, slight increase of the carotic arterial blood flow in most cases, significant rise of plasma histamine levels in portal vein, and imcomplete release of 5-HT from the enterochromaffin cells. These findings suggest that selective gastric vagotomy will prevent the dumping syndrome.