The Effect of Tetragastrin on Gastric Emptying in Normal and Ulcer Subjects

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Effect of tetragastrin on gastric emptying was studied in 20 normal subjects and 14 patientswith gastric ulcer scar. All subjects were tested with following examinations:1) Gastric analysis with intramuscular injection of tetragastrin 4γ/kg.2) Gastric emptying test by the double sampling method after George and Mizuno, using 300ml of 5% glucose solution as a test meal, for 20 minutes.3) Gastric emptying test, described in 2), added with intramuscular injection of tetragastrin2γ/kg at instillation of test meal. Thirteen of 20 normal subjects were additionarilytested with gastric emptying using 4γ/kg tetragastrin injection instead of 2γ/kg.Results were as follows:Tetragastrin generally delayed gastric emptying with mode of dose-response. It wassuggested that delay of gastric emptying by tetragastrin might be caused by its direct affectionto the gastric muscles.In hyposecretory cases with OAO less than 6mEq/h among normal subjects, stimulationof tetragastrin 2γ/kg rather accelerated gastric emptying. It was speculated that theduodenal brake mechanism could be important in control of gastric emptying.In hyposecretory cases among patients with gastric ulcer scar, there were a few caseswho showed delay of gastric emptying by injection of tetragastrin 2γ/kg. Duodenal brakemight etiologically reffer to gastric ulcer.
財団法人日本消化器病学会の論文