CYTOTOXICITY OF PERIPHERAL LYMPHOCYTES FROM PATIENTS WITH HEPATOMA ON HUMAN HEPATOMA CELL LINE:II. Spontaneous Lymphocyte Mediated Cytotoxicity in Patients with Chronic Liver Diseases and Healthy Subjects Compared with Patients with Hepatoma

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概要

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• The cytotoxic activity of peripheral blood lymphocytes was investigated in cases of chronic hepatitis, liver cirrhosis and hepatoma by microcytotoxicity assay. The cytotoxicity against HeLa cell was significantly decreased in cases of chronic hepatitis and liver cirrhosis but not significant in patients with hepatoma.The cytotoxicity against hepatoma cell line (LiC-1 Ohtsuka) was decreased in cases of liver cirrhosis and hepatoma but not significant.Non T cell fraction showed cytotoxicity against HeLa cell and hepatoma cell line either. Scanning electron microscopy revealed numerous microvilli on cell suface of the lymphocytes which were in process of destroying target hepatoma cell in vitro. It was considered that"spontaneous lymphocyte mediated cytotoxicity"by non T cell was detected in microcytotoxicity assay.For the T cell fraction of lymphocytes from the patients with hepatoma didn't show the cytotoxicity against hepatoma cell line, it could be concluded that cytotoxic T lymphocytes might not be induced in patients with hepatoma.

• 財団法人 日本消化器病学会の論文

著者

• 大塚 秋二郎

  慶応義塾大学医学部外科

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• CYTOTOXICITY OF PERIPHERAL LYMPHOCYTES FROM PATIENTS WITH HEPATOMA ON HUMAN HEPATOMA CELL LINE:II. Spontaneous Lymphocyte Mediated Cytotoxicity in Patients with Chronic Liver Diseases and Healthy Subjects Compared with Patients with Hepatoma

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