EXPERIMENTAL STUDIES ON SERUM GASTRIN LEVELS AND IMMUNOREACTIVE GASTRIN CONCENTRATIONS IN THE GASTROINTESTINAL MUCOSA OF RATS:(2) Changes Following Feeding Conditions

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Changes of serum gastrin levels and immunoreactive gastrin (IRG) concentrations in the antral mucosa of rats following low protein feeding and in condition of starvation were examined. The results obtained were as follows;1) Low protein feeding showed few influence on serum gastrin levels, whereas the antral IRG concentrations showed decrease in group with low protein feeding compared to group with ordinary food feeding.2) Significant decreases of serum gastrin levels and the antral IRG concentrations were seen in group kept in starved conditions (p<0.05).3) Control group which was kept in freely food intake condition showed significant increases of both serum gastrin levels and antral IRG concentrations (p<0.05, p<0.41) compared with those of groups in starved conditions.Summarizing the results, it was clarified that the feeding as well as the protein contents of food played an important physiological role in the production, storage and release mechanism of gastrin.
財団法人日本消化器病学会の論文