香粧品香料に関する研究 : 無刺激性セッケン香料について
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In order to get practically non-irritative compounded perfumes for soaps, the authors carried out the primary irritation tests of 19 kinds of natural and 43 kinds of synthetic perfumes by the closed patch test on the human skin.<BR>The test conditions were as follows : Total subjects of 11, 357 of males and females with both normal and dermatoses, 0.05-20% of administration levels in media such as vaseline, ointment, non-irritative cream base and 99% ethanol. Positive reactions were observed with several natural and synthetic perfumes within 24-72 hrs after application.<BR>Based on the results, the authors formulated seven kinds of compounded perfumes for soaps by use of the milder odorous materials. The primary irritation and photo toxicity tests of the said compounded perfumes were carried out by the patch test. The administration level was 20% of the substances in olive oil as medium. Seventy seven males and females with a variety of dermatoses were exclusively tested for subjects, and 1.3-5.2% of the subjects showed the positve reaction by the patch test. Regarding the condition of the subjects and application level, the range of percentage is considered not to be so high. The result of the photo patch tests was negative in all cases.<BR>As the quantity of the compounded perfume used in soaps is usually 1-2%, the skin irritation which might be caused by the perfumes is thought to be quite weak from the practical view point.
- 社団法人 日本油化学会の論文
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