自動酸化リノレン酸メチル多量体によるトリプシノーゲン活性化阻害

概要

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The main oxidized products of methyl linolenate such as a polymer, methyl linolenate monohydroperoxides (MLnHPO), and degraded products considerably effected the activation of trypsinogen.<BR>The polymer inhibited the activation of trypsinogen more than MLnHPO, whereas, the degraded products accelarated the activation. The inhibitory action of the polymer depended on the production of insoluble trypsinogen during the reaction of trypsinogen with the polymer. This substance contained a trypsinogen monomer but not trypsinogen polymerized by the intermolecular cross-linking of trypsinogen. 1.7 to 3.9 mol of the polymer were found to be bound covalently to 1 mol of trypsinogen as a complex in the insoluble substance.
社団法人日本油化学会の論文